RESM

    

Submission & tracking

For submitting new manuscripts or tracking the existing ones, login or register to the Submission Tracking System.


LOGIN / REGISTER

Special issue

Special Issue Proposals:

The journal of RESM is open to proposals for special issues on emerging related topics. More info is here.

UPCOMING events

PARTNERS




Research Article

Self-powered microfluidic device for the colorimetric detection of lithium via sequential reagent mixing

Angelo Traina1,2, Han J.G.E. Gardeniers1, Burcu Gumuscu1,3,4

1Mesoscale Chemical Systems Group, University of Twente, Enschede, The Netherlands

2Department Information Engineering, Electronics and Telecommunications, Sapienza University of Rome, Rome, Italy

3BioInterface Science Group, Eindhoven University of Technology, Eindhoven, The Netherlands

4Biosensors and Devices Group, Eindhoven University of Technology, Eindhoven, The Netherlands

Keywords

Abstract




Lithium detection;

 Colorimetric detection; 

Microfluidic circuits; 

Finger-driven pump.



Continuous monitoring of lithium concentration fluctuations in blood plasma is essential for patients with bipolar disorder and manic depression since lithium has a low therapeutic index. While blood plasma concentrations between 0.4 and 1.0 mmol/L are considered to be in the therapeutic zone, the concentrations exceeding 1.3 mmol/L are toxic to the patients. Most of the point-of-care devices for lithium monitoring have bulky peripherals and require extensive operator handling, yet simple-to-use devices are in demand for 2–5% of the worldwide population receiving lithium therapy. This paper aims to develop a self-contained microfluidic device to run colorimetric lithium assays without the need for dedicated personnel or equipment. In the developed microchip, the assay reagents are mixed in sequential order via custom-designed microfluidic capillary circuits with the aid of a finger pump. The operation of the finger pump was characterized mathematically and demonstrated experimentally. The finger-driven pump achieved 45.9 mm/s flow velocity when 8.3 µL liquid was placed in a 160 mm long channel with 200 µm height, as such rapid triggering was a requirement for the colorimetric lithium test. The final device is able to quantify the lithium concentrations between 0 and 2.0 mM using a smartphone camera. The detection limit of this microchip was calculated as 0.1 mM. This device presents a portable alternative to on-site quantitative detection techniques with bulky and expensive tools.

© 2021 MIM Research Group. All rights reserved.

LATEST News


13/04/2022 Fraudulent Emails Impersonating Our Journal: We noticed that some emails are sent to some people impersonating our journal staff as sender and requesting recipients to follow some links. Our journal and staff has nothing to do with these emails and please do not follow the given links. Senders seem to have malicious aims. The emails include a portion of some of our previous emails to the journal users and researchers. This is only to deceive the receiver and make them trust the email. Do not follow any links or perform suspicious actions specified in these emails. Please, check the sender info carefully. Even the sender address or name resembles the journal related words they are different, generally in an easily noticeable way.


09/03/2022 Outstanding Reviewer Award: The reviewers are the anonymous heroes of the publishing society. Reviewing manuscripts is not an easy task but it is critical to the advancement of scientific knowledge. Even if authors take credit for publishing papers, the recognition of the reviewers are highly limited for their work. Therefore, our journal announces the reviewers that participated in editorial processes of the submitted articles in a yearly basis. Now, we expand our efforts to appreciate the valuable contribution of our reviewers and start to give Outstanding Reviewer Awards.


More info can be found at Reviewer Awards section. 


29/12/2021 Best Paper Award: According to the Advisory Board decision, the paper authored by Sahar Ismail, Wassim Raphael, Emmanuel Durand entitled as “Case study of the Beirut port explosion using 3D laser scan and nonlinear finite element model” is awarded the 2021 Best Paper Award of Research on Engineering Structures and Materials (RESM). We congratulate the authors and wish them a continued success.  



29/12/2021 Most Cited Paper Award: According to the Editorial Board evaluation, the paper authored by Sinan Kutluay, Orhan Baytar, Ömer Şahin entitled as “Adsorption kinetics, equilibrium and thermodynamics
of gas-phase toluene onto char produced from almond shells" is awarded the 2021 Most Cited Paper Award of Research on Engineering Structures and Materials (RESM). We congratulate the authors and wish them a continued success.


(More details of the news may be given in the News section)


For more see News...

LATEST AWARDS


2021 Best Paper Award:

The paper authored by Sahar Ismail, Wassim Raphael, Emmanuel Durand entitled as “Case study of the Beirut port explosion using 3D laser scan and nonlinear finite element model” is awarded the 



2021 Most Cited Paper Award:

The paper authored by Sinan Kutluay, Orhan Baytar, Ömer Şahin entitled as “Adsorption kinetics, equilibrium and thermodynamics of gas-phase toluene onto char produced from almond shells" is awarded the


abstractıng/ındexıng

  • Asos Indeks
  • CiteFactor
  • Cosmos
  • CrossRef
  • Directory of Research Journal Indexing
  • Engineering Journals (ProQuest)
  • EZB Electronic Journal Library
  • Global Impact Factor
  • Google Scholar
  • InfoBase Index
  • International Institute of Organized Research (I2OR)
  • International Scientific Indexing (ISI)
  • Materials Science & Engineering Database (ProQuest)
  • Open Academic Journals Index
  • Publication Forum
  • Research BibleScientific Indexing Service
  • Root Indexing
  • Scopus
  • Ulakbim TR Index (Tubitak)
  • Universal Impact Factor
  • Scope Database




MIM RESEARCH GROUP

©2014. All rights reserved

Contact :

jresm@jresm.net

editor.jresm@gmail.com


Postal Address:

Kemal Öz Mah. 3. Üniversite Sok. Erdoğan Apt. 70/21 Usak/Turkey



Last Update:

28.09.2022

(dd.mm.yyyy)